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Service description

SILVER-Seq™ (Small Input Liquid Volume Extracellular RNA Sequencing) efficiently sequences both integral and fragmented extracellular RNAs (exRNAs) from a small droplet (5–7 microliters) of liquid biopsy, including human serum, plasma, saliva, and aqueous humor. Users order by the number of liquid biopsy samples and Genemo will provide shipping instructions for users to ship the samples to Genemo. Genemo will carry out SILVER-Seq™ and provide the sequencing data to the users. Genemo will also provide to users processed SILVER-Seq™ data that include all the detected exRNAs including miRNAs, antisense RNAs, and exRNAs derived from lncRNAs and mRNAs and their expression levels (Tags Per Million, TPM).

Sample requirements

We accept four types of samples: serum, plasma, saliva, and aqueous humor. Sample volume should be at least 7µL. We recommend 15µL or more. Samples should be kept in nuclease-free (PCR clean) tubes and stored at -70°C to -80°C.

SILVER-Seq™ output

Genemo will perform a 75-cycle single-end sequencing for the submitted sample. The minimal number of reads per sample is 3 million. The sequencing results, including FASTQ files, mapping results, QC reports, can be downloaded from our data server.

How this works

  • Placing an order via email info@rnadiagnosis.com
  • Shipping samples to Genemo. We will provide confirmation upon receipt.
  • A pre-analytical quality check will be performed within three business days upon sample arrival. After the library construction, there will be a post-analytical quality check for the library concentration and size distribution. If it fails, we will contact you to discuss how the samples can be returned. While the service fee may be waived, but a QC processing fee may apply.
  • SILVER-Seq™ library construction, which will be completed within 20 days from sample arrival.
  • Sequencing and data processing.
  • Sequencing results available for download. This will be completed within 45 days from sample arrival.
0+ Processed samples
0 Clinical trials
0+ Year of clinical samples
0+ Insitutional customers

Pricing

We are here to help you to develop your RNA biomarkers. Please inquire for co-development pricing.

Academic

$399 / sample
  • Acceptable liquid types include serum, plasma, saliva, tears
  • 3+ million reads
  • 10,000+ transcripts
  • Return both sequencing raw data and sequencing mapping results

Industry

$699 / sample
  • Acceptable liquid types include serum, plasma, saliva, tears
  • 3+ million reads
  • 10,000+ transcripts
  • Return both sequencing raw data and sequencing mapping results

Bionformatics

$5000 / small project
  • Quality control analysis
  • Two sample comparison
  • Biomarker discovery
  • Stastistical assessments
  • Project reports

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